Targeted disruption of the mouse protein phosphatase ppm1l gene leads to structural abnormalities in the brain.

Abstract

PPM1L, a member of the metal-dependent protein phosphatase (PPM) family, is involved in regulating the stress-activated protein kinase pathway and ceramide trafficking. However, the physiological function of PPM1L in the brain is unclear. In this study, we generated and analyzed ppm1l-deficient mice in order to investigate PPM1L functions in the brain. Our… (More)
DOI: 10.1002/1873-3468.12429

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@article{Kusano2016TargetedDO, title={Targeted disruption of the mouse protein phosphatase ppm1l gene leads to structural abnormalities in the brain.}, author={Rie Kusano and Kousuke Fujita and Yasuharu Shinoda and Yuko Nagaura and Hiroshi Kiyonari and Takaya Abe and Toshio Watanabe and Yasuhisa Matsui and Masahiro Fukaya and Hiroyuki Sakagami and Tatsuya Sato and J. Funahashi and Motoko Ohnishi and Shinri Tamura and Takayasu Kobayashi}, journal={FEBS letters}, year={2016}, volume={590 20}, pages={3606-3615} }