Targeted disruption of the mouse beta1-adrenergic receptor gene: developmental and cardiovascular effects.

@article{Rohrer1996TargetedDO,
  title={Targeted disruption of the mouse beta1-adrenergic receptor gene: developmental and cardiovascular effects.},
  author={Daniel K. Rohrer and Kavin H Desai and Jeffrey R. Jasper and M. D. Cladd E. Stevens and Donald P. Regula and Gregory S Barsh and D. Bernstein and Brian K. Kobilka},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 14},
  pages={
          7375-80
        }
}
At least three distinct beta-adrenergic receptor (beta-AR) subtypes exist in mammals. These receptors modulate a wide variety of processes, from development and behavior, to cardiac function, metabolism, and smooth muscle tone. To understand the roles that individual beta-AR subtypes play in these processes, we have used the technique of gene targeting to create homozygous beta 1-AR null mutants (beta 1-AR -/-) in mice. The majority of beta 1-AR -/- mice die prenatally, and the penetrance of… CONTINUE READING