Targeted disruption of the mouse lecithin:cholesterol acyltransferase (LCAT) gene. Generation of a new animal model for human LCAT deficiency.

@article{Sakai1997TargetedDO,
  title={Targeted disruption of the mouse lecithin:cholesterol acyltransferase (LCAT) gene. Generation of a new animal model for human LCAT deficiency.},
  author={Noriko Sakai and Boris L Vaisman and Christine Anne Koch and Robert F. Hoyt and Susan M Meyn and Glenda D Talley and J A Paiz and Hollis B Brewer and Silvia Santamarina-Fojo},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 11},
  pages={7506-10}
}
We have established a mouse model for human LCAT deficiency by performing targeted disruption of the LCAT gene in mouse embryonic stem cells. Homozygous LCAT-deficient mice were healthy at birth and fertile. Compared with age-matched wild-type littermates, the LCAT activity in heterozygous and homozygous knockout mice was reduced by 30 and 99%, respectively. LCAT deficiency resulted in significant reductions in the plasma concentrations of total cholesterol, HDL cholesterol, and apoA-I in both… CONTINUE READING

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Targeted disruption of the mouse lecithin : cholesterol acyltransferase ( LCAT ) gene .
Targeted disruption of the mouse lecithin : cholesterol acyltransferase ( LCAT ) gene .
Targeted disruption of the mouse lecithin : cholesterol acyltransferase ( LCAT ) gene .
Targeted disruption of the mouse lecithin : cholesterol acyltransferase ( LCAT ) gene .
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