Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality.

@article{Takeda1997TargetedDO,
  title={Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality.},
  author={K. Takeda and K. Noguchi and W. Shi and T. Tanaka and M. Matsumoto and N. Yoshida and T. Kishimoto and S. Akira},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 8},
  pages={
          3801-4
        }
}
  • K. Takeda, K. Noguchi, +5 authors S. Akira
  • Published 1997
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
Signal transducer and activator of transcription (STAT) proteins have been shown to mediate biological actions in response to cytokines. Stat3, a member of the STAT family, is activated by a variety of cytokines, including the interleukin 6 family of cytokines, leptin, granulocyte colony-stimulating factor, and epidermal growth factor. To address the biological function of Stat3, we generated mice deficient in Stat3 by gene targeting. No viable Stat3-deficient mice could be obtained from… Expand
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  • K. Takeda, S. Akira
  • Biology, Medicine
  • Archivum immunologiae et therapiae experimentalis
  • 2001
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In an attempt to avoid the lethality and assess the role of Stat3 in cytokine-mediated functions in mouse adult tissues, conditional gene targeting utilizing a Cre-loxP system was achieved and Stat3 was disrupted in several types of tissue. Expand
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  • Developmental dynamics : an official publication of the American Association of Anatomists
  • 2004
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Zebrafish stat3 is expressed in restricted tissues during embryogenesis and stat1 rescues cytokine signaling in a STAT1‐deficient human cell line
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  • Biology, Medicine
  • Developmental dynamics : an official publication of the American Association of Anatomists
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References

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Cell and tissues from Stat1(-1-1) mice were unresponsive to IFN, but remained responsive to all other cytokines tested, indicating that STAT1 appears to be specific for IFN pathways that are essential for viability in the face of otherwise innocuous pathogens. Expand
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The structure of the mouse STAT3 gene was almost identical to that of the human STAT2 gene, including the number and size of exons, indicating that the exon-intron organization had already been accomplished before these two genes duplicated, and then these genes evolved to respond to different ligands. Expand
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