Targeted disruption of the melanin-concentrating hormone receptor-1 results in hyperphagia and resistance to diet-induced obesity.

@article{Chen2002TargetedDO,
  title={Targeted disruption of the melanin-concentrating hormone receptor-1 results in hyperphagia and resistance to diet-induced obesity.},
  author={Yanyun Chen and Changzhi Hu and Chiun-Kang Hsu and Qing Zhang and Chen long Bi and Mark A Asnicar and Hansen M. Hsiung and Niles Fox and Lawrence J. Slieker and Derek Yang and Mark L. Heiman and Yuguang Shi},
  journal={Endocrinology},
  year={2002},
  volume={143 7},
  pages={2469-77}
}
The hypothalamic neuropeptide melanin-concentrating hormone (MCH) has been implicated in a variety of physiological functions including the regulation of feeding and energy homeostasis. Two MCH receptors (MCHR1 and MCHR2) have been identified so far. To decipher the functional role of the MCH receptors, we have generated and phenotypically characterized mice rendered deficient in MCHR1 expression by homologous recombination. Inactivation of MCHR1 results in mice (MCHR1-/-) that are resistant to… CONTINUE READING