Targeted disruption of the galectin-3 gene results in decreased susceptibility to multiple low dose streptozotocin-induced diabetes in mice.

Abstract

Galectin 3 (Gal-3) is an antiapoptotic and a proinflammatory lectin. We hypothesized that the proinflammatory properties of Gal-3 may influence disease induction in the multiple low doses of streptozotocin model of diabetes. Diabetes was induced in C57BL/6 Gal-3(+/+) and Gal-3(-/-) mice and disease monitored by blood glucose level, immuno-histology, insulin… (More)
DOI: 10.1016/j.clim.2008.08.024

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@article{MensahBrown2009TargetedDO, title={Targeted disruption of the galectin-3 gene results in decreased susceptibility to multiple low dose streptozotocin-induced diabetes in mice.}, author={E P K Mensah-Brown and Z Al Rabesi and Allen Shahin and Mariam S Al Shamsi and Natalija Arsenijevic and Daniel Hsu and F T Liu and Miodrag L. Luki{\'c}}, journal={Clinical immunology}, year={2009}, volume={130 1}, pages={83-8} }