Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors.

@article{Mackarehtschian1995TargetedDO,
  title={Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors.},
  author={K Mackarehtschian and Jeffrey D. Hardin and Kateri Moore and Sharon Boast and Stephen P Goff and Ihor Lemischka},
  journal={Immunity},
  year={1995},
  volume={3 1},
  pages={147-61}
}
The flk2 receptor tyrosine kinase has been implicated in hematopoietic development. Mice deficient in flk2 were generated. Mutants developed into healthy adults with normal mature hematopoietic populations. However, they possessed specific deficiencies in primitive B lymphoid progenitors. Bone marrow transplantation experiments revealed a further deficiency… CONTINUE READING