Targeted disruption of the even-skipped gene, evx1, causes early postimplantation lethality of the mouse conceptus.

@article{Spyropoulos1994TargetedDO,
  title={Targeted disruption of the even-skipped gene, evx1, causes early postimplantation lethality of the mouse conceptus.},
  author={Demetri D. Spyropoulos and Mario R Capecchi},
  journal={Genes & development},
  year={1994},
  volume={8 16},
  pages={1949-61}
}
Implantation within the mammalian uterus elicits dramatic changes in the growth, differentiation, and morphogenesis of the conceptus. This process is interrupted in mice carrying a targeted disruption of the murine evx1 gene, a homolog of the Drosophila even-skipped (eve) gene. Upon implantation, presumptive evx1- homozygotes elicit a decidual response, invade the uterine epithelium, and attach to the basement membrane between uterine stroma and epithelium, but fail to differentiate… CONTINUE READING