Targeted disruption of the cardiac troponin T gene causes sarcomere disassembly and defects in heartbeat within the early mouse embryo.

@article{Nishii2008TargetedDO,
  title={Targeted disruption of the cardiac troponin T gene causes sarcomere disassembly and defects in heartbeat within the early mouse embryo.},
  author={K. Nishii and S. Morimoto and R. Minakami and Yumi Miyano and K. Hashizume and M. Ohta and D. Zhan and Q. Lu and Y. Shibata},
  journal={Developmental biology},
  year={2008},
  volume={322 1},
  pages={
          65-73
        }
}
Cardiac troponin T (cTnT) is a component of the troponin (Tn) complex in cardiac myocytes, and plays a regulatory role in cardiac muscle contraction by anchoring two other Tn components, troponin I (TnI) and troponin C, to tropomyosin (Tm) on the thin filaments. In order to determine the in vivo function of cTnT, we created a null cTnT allele in the mouse TNNT2 locus. In cTnT-deficient (cTnT(-/-)) cardiac myocytes, the thick and thin filaments and alpha-actinin-positive Z-disk-like structures… Expand
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