Targeted disruption of the basic Krüppel-like factor gene (Klf3) reveals a role in adipogenesis.

  title={Targeted disruption of the basic Kr{\"u}ppel-like factor gene (Klf3) reveals a role in adipogenesis.},
  author={Nancy Sue and Briony H A Jack and Sally A. Eaton and Richard C. M. Pearson and Alister P. W. Funnell and Jeremy Turner and Robert Czolij and Gareth S. Denyer and Shisan Bao and Juan Carlos Molero-Navajas and Andrew Perkins and Yuko Fujiwara and Stuart H Orkin and Kim S. Bell-Anderson and Merlin Crossley},
  journal={Molecular and cellular biology},
  volume={28 12},
Krüppel-like factors (KLFs) recognize CACCC and GC-rich sequences in gene regulatory elements. Here, we describe the disruption of the murine basic Krüppel-like factor gene (Bklf or Klf3). Klf3 knockout mice have less white adipose tissue, and their fat pads contain smaller and fewer cells. Adipocyte differentiation is altered in murine embryonic fibroblasts from Klf3 knockouts. Klf3 expression was studied in the 3T3-L1 cellular system. Adipocyte differentiation is accompanied by a decline in… CONTINUE READING