Targeted disruption of the PEPT2 gene markedly reduces dipeptide uptake in choroid plexus.

@article{Shen2003TargetedDO,
  title={Targeted disruption of the PEPT2 gene markedly reduces dipeptide uptake in choroid plexus.},
  author={Hong Shen and David E Smith and Richard F. Keep and Jianming Xiang and Frank C. Brosius},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 7},
  pages={4786-91}
}
The presence of multiple oligopeptide transporters in brain has generated considerable interest as to their physiological role in neuropeptide homeostasis, pharmacologic importance, and potential as a target for drug delivery through the blood-brain and blood-cerebrospinal fluid barriers. To understand further the purpose of specific peptide transporters in brain, we have generated PEPT2-deficient mice by targeted gene disruption. Homozygous PepT2 null mice lacked expression of PEPT2 mRNA and… CONTINUE READING
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