Targeted disruption of the Oct-2 locus in a B cell provides genetic evidence for two distinct cell type-specific pathways of octamer element-mediated gene activation.

@article{Feldhaus1993TargetedDO,
  title={Targeted disruption of the Oct-2 locus in a B cell provides genetic evidence for two distinct cell type-specific pathways of octamer element-mediated gene activation.},
  author={Andrew L Feldhaus and Christopher A. Klug and Kara L Arvin and Harinder Singh},
  journal={The EMBO journal},
  year={1993},
  volume={12 7},
  pages={2763-72}
}
The Oct-2 protein is a tissue-specific POU-homeodomain transcription factor. It has been considered to represent a developmental regulator of immunoglobulin gene expression by virtue of its interaction with a functionally essential octamer element found in immunoglobulin gene promoters. This proposal has been most strongly challenged by several in vitro transcription analyses which have shown that the related ubiquitous factor Oct-1 can activate transcription from immunoglobulin gene promoters… CONTINUE READING
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