Targeted disruption of the Mn1 oncogene results in severe defects in development of membranous bones of the cranial skeleton.

@article{MeesterSmoor2005TargetedDO,
  title={Targeted disruption of the Mn1 oncogene results in severe defects in development of membranous bones of the cranial skeleton.},
  author={Magda A. Meester-Smoor and M. J. M. Vermeij and Marjolein J L van Helmond and Anco C Molijn and Karel H. M. van Wely and Arnold C P Hekman and Christl Vermey-Keers and Peter Riegman and Ellen C. Zwarthoff},
  journal={Molecular and cellular biology},
  year={2005},
  volume={25 10},
  pages={4229-36}
}
Fusion of the MN1 gene to TEL (ETV6) results in myeloid leukemia. The fusion protein combines the transcription activating domain of MN1 and the DNA binding domain of TEL and is thought to act as a deranged transcription factor. In addition, disruption of the large first exon of the MN1 gene is thought to inactivate MN1 function in a meningioma. To further investigate the role of MN1 in cancer, we generated Mn1 knockout mice. Mn1(+/-) animals were followed for 30 months, but they had no higher… CONTINUE READING
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