Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes

@article{Nasir1995TargetedDO,
  title={Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes},
  author={J. Nasir and S. Floresco and J. O’Kusky and V. Diewert and Joy Richman and J. Zeisler and A. Borowski and J. Marth and A. Phillips and M. Hayden},
  journal={Cell},
  year={1995},
  volume={81},
  pages={811-823}
}
Huntington's disease (HD) is an incurable neuropsychiatric disease associated with CAG repeat expansion within a widely expressed gene that causes selective neuronal death. To understand its normal function, we have created a targeted disruption in exon 5 of Hdh (Hdhex5), the murine homolog of the HD gene. Homozygotes die before embryonic day 8.5, initiate gastrulation, but do not proceed to the formation of somites or to organogenesis. Mice heterozygous for the Hdhex5 mutation display… Expand
Inactivation of the mouse Huntington's disease gene homolog Hdh.
Lessons from animal models of Huntington's disease.
Transgenic models of Huntington's disease.
  • K. Sathasivam, C. Hobbs, +5 authors G. Bates
  • Biology, Medicine
  • Philosophical transactions of the Royal Society of London. Series B, Biological sciences
  • 1999
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