Targeted disruption of the Ca2+ channel beta3 subunit reduces N- and L-type Ca2+ channel activity and alters the voltage-dependent activation of P/Q-type Ca2+ channels in neurons.

@article{Namkung1998TargetedDO,
  title={Targeted disruption of the Ca2+ channel beta3 subunit reduces N- and L-type Ca2+ channel activity and alters the voltage-dependent activation of P/Q-type Ca2+ channels in neurons.},
  author={Yoon Namkung and Sean M. Smith and Sung Bae Lee and Nataliya V. Skrypnyk and Hyung L. Kim and Hemin R. Chin and Richard Henry Scheller and Richard W. Tsien and Ho Seob Shin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 20},
  pages={
          12010-5
        }
}
In comparison to the well characterized role of the principal subunit of voltage-gated Ca2+ channels, the pore-forming, antagonist-binding alpha1 subunit, considerably less is understood about how beta subunits contribute to neuronal Ca2+ channel function. We studied the role of the Ca2+ channel beta3 subunit, the major Ca2+ channel beta subunit in neurons, by using a gene-targeting strategy. The beta3 deficient (beta3-/-) animals were indistinguishable from the wild type (wt) with no gross… CONTINUE READING
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