Targeted disruption of the CD3 eta locus causes high lethality in mice: modulation of Oct-1 transcription on the opposite strand.

@article{Ohno1994TargetedDO,
  title={Targeted disruption of the CD3 eta locus causes high lethality in mice: modulation of Oct-1 transcription on the opposite strand.},
  author={Hiroshi Ohno and Satoshi Goto and Shinsuke Taki and Takuo Shirasawa and Hiroyasu Nakano and Shoichiro Miyatake and Tomohiko Aoe and Yuko Ishida and Hiroshi Maeda and Toshikazu Shirai},
  journal={The EMBO journal},
  year={1994},
  volume={13 5},
  pages={1157-65}
}
CD3 zeta and eta chains are components of the T cell antigen receptor (TCR) complex and are transcribed from a common gene by alternative splicing. TCR complexes containing the zeta eta dimer have been thought to mediate different functions than complexes containing the zeta 2 dimer. To analyze the role of eta in the development and function of T cells, we generated eta-deficient mice without affecting zeta by gene targeting in embryonic stem cells. Homozygous mutant embryos developed normally… CONTINUE READING
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