Targeted disruption of p107: functional overlap between p107 and Rb.

  title={Targeted disruption of p107: functional overlap between p107 and Rb.},
  author={Myung Hae Lee and Bart O. Williams and Guy Mulligan and Shizuo Mukai and Roderick Terry Bronson and Nicholas Dyson and E E Harlow and Tyler 8 Jacks},
  journal={Genes & development},
  volume={10 13},
To explore the physiological role of p107, a member of retinoblastoma gene (Rb) family, we disrupted the mouse gene by homologous recombination in embryonic stem cells. p107 homozygous mutant mice were viable, fertile, and displayed no obvious abnormalities. To investigate possible functional overlap between p107 and Rb, mice with mutations at both loci were generated. Rb+/-;p107-/- mice have a pronounced growth retardation and increased mortality rate during the first 3 weeks after birth. The… CONTINUE READING

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