Targeted disruption of mouse long-chain acyl-CoA dehydrogenase gene reveals crucial roles for fatty acid oxidation.

@article{Kurtz1998TargetedDO,
  title={Targeted disruption of mouse long-chain acyl-CoA dehydrogenase gene reveals crucial roles for fatty acid oxidation.},
  author={David M Kurtz and Piero Rinaldo and William James Rhead and Liqun Tian and David S. Millington and Jerry Vockley and Doug A Hamm and Amy E Brix and J. Russell Lindsey and Carl A. Pinkert and William E O'brien and Philip A. Wood},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 26},
  pages={15592-7}
}
Abnormalities of fatty acid metabolism are recognized to play a significant role in human disease, but the mechanisms remain poorly understood. Long-chain acyl-CoA dehydrogenase (LCAD) catalyzes the initial step in mitochondrial fatty acid oxidation (FAO). We produced a mouse model of LCAD deficiency with severely impaired FAO. Matings between LCAD +/- mice yielded an abnormally low number of LCAD +/- and -/- offspring, indicating frequent gestational loss. LCAD -/- mice that reached birth… CONTINUE READING
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