Targeted disruption of histamine H1-receptor attenuates regulatory effects of leptin on feeding, adiposity, and UCP family in mice.

@article{Masaki2001TargetedDO,
  title={Targeted disruption of histamine H1-receptor attenuates regulatory effects of leptin on feeding, adiposity, and UCP family in mice.},
  author={Takayuki Masaki and Hironobu Yoshimatsu and Seiichi Chiba and Takeshi Watanabe and Toshiie Sakata},
  journal={Diabetes},
  year={2001},
  volume={50 2},
  pages={385-91}
}
Histamine neurons are widely distributed in the brain and suppress food intake through the histamine H1 receptor (H1-R) in the hypothalamus. To examine the role of neuronal histamine in leptin signaling pathways, we investigated the effects of H1-R knockout (H1KO) mice on both food intake and mRNA expressions of uncoupling proteins (UCPs) as regulated by leptin, and concomitantly on basal changes in both expression of hypothalamic neuropeptides and diet-induced fat deposition in adipose tissues… CONTINUE READING

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CB: Distributions of leptin receptor mRNA isoforms in the rat brain

JK Elmquist, C Bjorbaek, RS Ahima, JS Flier, Saper
J Comp Neurol 395:535–547, • 1998

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