Targeted disruption of beta1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction.

@article{White2004TargetedDO,
  title={Targeted disruption of beta1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction.},
  author={Donald E. White and Natasza A. Kurpios and Dongmei Zuo and John A. Hassell and Sandra Blaess and Ulrich F M{\"u}ller and William J. Muller},
  journal={Cancer cell},
  year={2004},
  volume={6 2},
  pages={
          159-70
        }
}
Despite evidence demonstrating the role of beta1-integrin in the regulation of cancer cell proliferation in vitro, the importance of this cell adhesion receptor during the initiation and progression of epithelial tumors in vivo remains unclear. Here we have used the Cre/LoxP1 recombination system to disrupt beta1-integrin function in the mammary epithelium of a transgenic mouse model of human breast cancer. Using this approach, we show that beta1-integrin expression is critical for the… CONTINUE READING
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