Targeted disruption of beta-catenin in Sf1-expressing cells impairs development and maintenance of the adrenal cortex.

@article{Kim2008TargetedDO,
  title={Targeted disruption of beta-catenin in Sf1-expressing cells impairs development and maintenance of the adrenal cortex.},
  author={Alex C. Kim and Anne L Reuter and Mohamad Zubair and Tobias Else and Kerri Serecky and Nathan C Bingham and Gareth G Lavery and Keith L. Parker and Gary D Hammer},
  journal={Development},
  year={2008},
  volume={135 15},
  pages={2593-602}
}
The nuclear receptor steroidogenic factor 1 (Sf1, Nr5a1) is essential for adrenal development and regulates genes that specify differentiated adrenocortical function. The transcriptional coactivator beta-catenin reportedly synergizes with Sf1 to regulate a subset of these target genes; moreover, Wnt family members, signaling via beta-catenin, are also implicated in adrenocortical development. To investigate the role of beta-catenin in the adrenal cortex, we used two Sf1/Cre transgenes to… CONTINUE READING

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