Targeted disruption of adrenomedullin and alphaCGRP genes reveals their distinct biological roles.

@article{Kurihara2003TargetedDO,
  title={Targeted disruption of adrenomedullin and alphaCGRP genes reveals their distinct biological roles.},
  author={Hiroki Kurihara and T. Shindo and Yoshio Oh-hashi and Yukiko Kurihar and Tomoyuki Kuwaki},
  journal={Hypertension research : official journal of the Japanese Society of Hypertension},
  year={2003},
  volume={26 Suppl},
  pages={S105-8}
}
Adrenomedullin (AM) and calcitonin gene-related peptide (CGRP) share common structural characteristics and receptors and belong to the same peptide family. Both peptides show a diverse set of biological effects including vasodilation. Recent establishment of gene-knockout mice has revealed the physiological importance of these two peptides. AM -/- mice demonstrated defective vascular formation during embryogenesis and did not survive beyond midgestation. AM +/- heterozygous mice showed high… CONTINUE READING