Targeted disruption of TRAF3 leads to postnatal lethality and defective T-dependent immune responses.

@article{Xu1996TargetedDO,
  title={Targeted disruption of TRAF3 leads to postnatal lethality and defective T-dependent immune responses.},
  author={Yunjian Xu and George Chen-hsi Cheng and David Baltimore},
  journal={Immunity},
  year={1996},
  volume={5 5},
  pages={407-15}
}
TRAF3 was found as a protein that binds to the cytoplasmic tail of CD40 but is part of a family of proteins with common structure and activity. To clarify the physiological roles of TRAF3, we introduced a TRAF3 null mutation in mice through homologous recombination. TRAF3-deficient mice appear normal at birth but become progressively runted, correlating with progressive hypoglycemia and depletion of peripheral white cells. The mutant mice die by 10 days of age. Fetal liver cells from TRAF3… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
78 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 78 extracted citations

Similar Papers

Loading similar papers…