Targeted disruption of Ras-Grf2 shows its dispensability for mouse growth and development.

Abstract

The mammalian Grf1 and Grf2 proteins are Ras guanine nucleotide exchange factors (GEFs) sharing a high degree of structural homology, as well as an elevated expression level in central nervous system tissues. Such similarities raise questions concerning the specificity and/or redundancy at the functional level between the two Grf proteins. grf1-null mutant… (More)

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Cite this paper

@article{FernndezMedarde2002TargetedDO, title={Targeted disruption of Ras-Grf2 shows its dispensability for mouse growth and development.}, author={Alberto Fern{\'a}ndez-Medarde and Luis Miguel Pedrero Esteban and Alejandro Flores Nunez and {\'A}ngel Porteros and Lino Tessarollo and Eugenio Santos}, journal={Molecular and cellular biology}, year={2002}, volume={22 8}, pages={2498-504} }