Targeted disruption of ROCK1 causes insulin resistance in vivo.

  title={Targeted disruption of ROCK1 causes insulin resistance in vivo.},
  author={Dae Ho Lee and Jianjian Shi and Nam Ho Jeoung and Min Seon Kim and Janice M. Zabolotny and Sam W. Lee and Morris F. White and Lei Wei and Young-Bum Kim},
  journal={The Journal of biological chemistry},
  volume={284 18},
Insulin signaling is essential for normal glucose homeostasis. Rho-kinase (ROCK) isoforms have been shown to participate in insulin signaling and glucose metabolism in cultured cell lines. To investigate the physiological role of ROCK1 in the regulation of whole body glucose homeostasis and insulin sensitivity in vivo, we studied mice with global disruption of ROCK1. Here we show that, at 16-18 weeks of age, ROCK1-deficient mice exhibited insulin resistance, as revealed by the failure of blood… CONTINUE READING


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Publications referenced by this paper.

National InstitutesHealth (1996)Guide for theCare andUse of Laboratory Animals, National Institutes of Health Publication Number 85-23

Y. B. Kim
March 10, • 2009

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