Targeted disruption of LH receptor gene revealed the importance of uterine LH signaling.

@article{Lin2005TargetedDO,
  title={Targeted disruption of LH receptor gene revealed the importance of uterine LH signaling.},
  author={D X Lin and Zhemin Lei and Xiangdong Li and Ch Venkateswara Rao},
  journal={Molecular and cellular endocrinology},
  year={2005},
  volume={234 1-2},
  pages={105-16}
}
Numerous previous studies have demonstrated that LH and hCG can directly regulate several uterine functions. We investigated in the present study, whether uterine phenotype in LH receptor knockout animals resulted also from the absence of direct actions of LH in the uterus. The phenotype consisted of marked growth reduction of uterus, decreased thickness of endometrial and myometrial layers, number of endometrial glands, height of luminal epithelium and vascular space. Analysis of uterine gene… CONTINUE READING