Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo.

@article{Sun1999TargetedDO,
  title={Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo.},
  author={Xuepeng Sun and Erik N. Meyers and Mark B Lewandoski and Gail R. Martin},
  journal={Genes & development},
  year={1999},
  volume={13 14},
  pages={1834-46}
}
Fgf8 and Fgf4 encode FGF family members that are coexpressed in the primitive streak of the gastrulating mouse embryo. We have analyzed the phenotype of Fgf8(-/-) embryos and discovered that they fail to express Fgf4 in the streak. In the absence of both FGF8 and FGF4, epiblast cells move into the streak and undergo an epithelial-to-mesenchymal transition, but most cells then fail to move away from the streak. As a consequence, no embryonic mesoderm- or endoderm-derived tissues develop… CONTINUE READING
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