Targeted disruption of ErbB2/Neu in the mammary epithelium results in impaired ductal outgrowth


The ErbB2 receptor tyrosine kinase has been implicated as a critical growth factor receptor in both normal development and cancer. Amplification and overexpression of this receptor is observed in 20–30% of all human breast cancers and is inversely correlated with patient survival. Studies with transgenic mice have established that elevated expression of… (More)
DOI: 10.1038/sj.onc.1208230

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