Targeted disruption of Adamts16 gene in a rat genetic model of hypertension.

@article{Gopalakrishnan2012TargetedDO,
  title={Targeted disruption of Adamts16 gene in a rat genetic model of hypertension.},
  author={Kathirvel Gopalakrishnan and Sivarajan Kumarasamy and Shakila Abdul-Majeed and Andrea L Nestor Kalinoski and Eric E Morgan and Amira F Gohara and Surya M. Nauli and Wanda E. Filipiak and Thomas L Saunders and Bina Joe},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 50},
  pages={20555-9}
}
A disintegrin-like metalloproteinase with thrombospondin motifs-16 (Adamts16) is an important candidate gene for hypertension. The goal of the present study was to further assess the candidacy of Adamts16 by targeted disruption of this gene in a rat genetic model of hypertension. A rat model was generated by manipulating the genome of the Dahl Salt-sensitive (S) rat using zinc-finger nucleases, wherein the mutant rat had a 17 bp deletion in the first exon of Adamts16, introducing a stop codon… CONTINUE READING
22 Citations
28 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 28 references

Increased expression of NAD(P)H oxidase subunit p67(phox) in the renal medulla contributes to excess oxidative stress and salt-sensitive hypertension

  • D Feng
  • Cell Metab 15(2):201–208
  • 2012
2 Excerpts

Report of the National Heart, Lung, and Blood Institute Working Group on epigenetics and hypertension

  • AW Cowley, Jr.
  • Hypertension
  • 2012
1 Excerpt

Re fi ned mapping of blood pressure quantitative trait loci using congenic strains developed from two genetically hypertensive rat models

  • S Kumarasamy
  • Hypertens Res
  • 2011

Similar Papers

Loading similar papers…