Targeted disruption of Adamts16 gene in a rat genetic model of hypertension.

  title={Targeted disruption of Adamts16 gene in a rat genetic model of hypertension.},
  author={Kathirvel Gopalakrishnan and Sivarajan Kumarasamy and Shakila Abdul-Majeed and Andrea L Nestor Kalinoski and Eric E Morgan and Amira F Gohara and Surya M. Nauli and Wanda E. Filipiak and Thomas L Saunders and Bina Joe},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={109 50},
A disintegrin-like metalloproteinase with thrombospondin motifs-16 (Adamts16) is an important candidate gene for hypertension. The goal of the present study was to further assess the candidacy of Adamts16 by targeted disruption of this gene in a rat genetic model of hypertension. A rat model was generated by manipulating the genome of the Dahl Salt-sensitive (S) rat using zinc-finger nucleases, wherein the mutant rat had a 17 bp deletion in the first exon of Adamts16, introducing a stop codon… CONTINUE READING
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