Targeted detection of in vivo endogenous DNA base damage reveals preferential base excision repair in the transcribed strand

@inproceedings{Reis2012TargetedDO,
  title={Targeted detection of in vivo endogenous DNA base damage reveals preferential base excision repair in the transcribed strand},
  author={Ant{\'o}nio M. C. Reis and Wilbur K. Mills and Ilangovan Ramachandran and Errol C. Friedberg and David Robert Martin Thompson and Lurdes Queimado},
  booktitle={Nucleic acids research},
  year={2012}
}
Endogenous DNA damage is removed mainly via base excision repair (BER), however, whether there is preferential strand repair of endogenous DNA damage is still under intense debate. We developed a highly sensitive primer-anchored DNA damage detection assay (PADDA) to map and quantify in vivo endogenous DNA damage. Using PADDA, we documented significantly higher levels of endogenous damage in Saccharomyces cerevisiae cells in stationary phase than in exponential phase. We also documented that… CONTINUE READING
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