Targeted delivery of thymosin beta 4 to the injured myocardium using CREKA-conjugated nanoparticles

Abstract

PURPOSE Thymosin beta 4 (Tβ4) has multiple beneficial facets for myocardial injury, but its efficiency is limited by the low local concentration within the infarct. Here, we established a Tβ4 delivery system for cardiac repair based on the interaction between the abundant fibrin in the infarct zone and the fibrin-targeting moiety clot-binding peptide… (More)
DOI: 10.2147/IJN.S131949

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