Targeted delivery of small interfering RNA to human dendritic cells to suppress dengue virus infection and associated proinflammatory cytokine production.

@article{Subramanya2010TargetedDO,
  title={Targeted delivery of small interfering RNA to human dendritic cells to suppress dengue virus infection and associated proinflammatory cytokine production.},
  author={Sandesh Subramanya and S. S. Kim and Sojan Abraham and Jiahong Yao and M. M. Swathanthira Kumar and P. Dileep Kumar and Viraga Haridas and Sang-Kyung Lee and Leonard D Shultz and Dale L. Greiner and N Manjunath and Premlata Shankar},
  journal={Journal of virology},
  year={2010},
  volume={84 5},
  pages={
          2490-501
        }
}
Dengue is a common arthropod-borne flaviviral infection in the tropics, for which there is no vaccine or specific antiviral drug. The infection is often associated with serious complications such as dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS), in which both viral and host factors have been implicated. RNA interference (RNAi) is a potent antiviral strategy and a potential therapeutic option for dengue if a feasible strategy can be developed for delivery of small interfering RNA… CONTINUE READING

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