Targeted delivery of siRNA to tumors using antibody-modified lipid nanoparticle

Abstract

SUMMARY Small interfering RNA (siRNA) has been expected to become a novel therapeutic agent to treat cancer. However, a delivery system to endow siRNA with long circulation in the bloodstream and with improved permeability through the plasma membrane is necessary for systemic use of siRNA in clinical. In the present study, lipid nanoparticle encapsulating… (More)

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