Targeted delivery of siRNA to activated T cells via transferrin-polyethylenimine (Tf-PEI) as a potential therapy of asthma.

Abstract

Asthma is a worldwide health problem. Activated T cells (ATCs) in the lung, particularly T helper 2 cells (Th2), are strongly associated with inducing airway inflammatory responses and chemoattraction of inflammatory cells in asthma. Small interfering RNA (siRNA) as a promising anti-sense molecule can specifically silence inflammation related genes in ATCs… (More)
DOI: 10.1016/j.jconrel.2016.03.029

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Cite this paper

@article{Xie2016TargetedDO, title={Targeted delivery of siRNA to activated T cells via transferrin-polyethylenimine (Tf-PEI) as a potential therapy of asthma.}, author={Yuran Xie and Na Hyung Kim and Venkatareddy Nadithe and Dana L. Schalk and Archana N. Thakur and Ayşe Kılıç and Lawrence G. Lum and David J. P. Bassett and Olivia M. Merkel}, journal={Journal of controlled release : official journal of the Controlled Release Society}, year={2016}, volume={229}, pages={120-9} }