Targeted delivery of antigen to hamster nasal lymphoid tissue with M-cell-directed lectins.

@article{Giannasca1997TargetedDO,
  title={Targeted delivery of antigen to hamster nasal lymphoid tissue with M-cell-directed lectins.},
  author={Paul J. Giannasca and Joan A. Boden and Thomas P Monath},
  journal={Infection and immunity},
  year={1997},
  volume={65 10},
  pages={
          4288-98
        }
}
The nasal cavity of a rodent is lined by an epithelium organized into distinct regional domains responsible for specific physiological functions. Aggregates of nasal lymphoid tissue (NALT) located at the base of the nasal cavity are believed to be sites of induction of mucosal immune responses to airborne antigens. The epithelium overlying NALT contains M cells which are specialized for the transcytosis of immunogens, as demonstrated in other mucosal tissues. We hypothesized that NALT M cells… CONTINUE READING
Highly Cited
This paper has 34 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

NALT (nasal cavity-associated lymphoid tissue) in the rabbit.

Veterinary immunology and immunopathology • 2010
View 4 Excerpts
Highly Influenced

Rational design of nasal vaccines.

Journal of drug targeting • 2008
View 2 Excerpts

References

Publications referenced by this paper.
Showing 1-10 of 63 references

Normal histology of the nasal cavity and application of special techniques.

Environmental health perspectives • 1990
View 10 Excerpts
Highly Influenced

Bronchial mucosal lymphoid tissue, p. 529–538

J. Bienenstock, R. Clancy
1994
View 4 Excerpts
Highly Influenced

The role of nasopharyngeal lymphoid tissue.

Immunology today • 1992
View 5 Excerpts
Highly Influenced