Targeted delivery of anti-cancer growth inhibitory peptides derived from human alpha-fetoprotein: review of an International Multi-Center Collaborative Study.

@article{Mizejewski2010TargetedDO,
  title={Targeted delivery of anti-cancer growth inhibitory peptides derived from human alpha-fetoprotein: review of an International Multi-Center Collaborative Study.},
  author={Gerald J. Mizejewski and Marek Mirowski and Piotr Garnuszek and Michelle Maurin and Bruce D. Cohen and Bernard J Poiesz and Galina A. Posypanova and Vladimir A. Makarov and Evgeny S Severin and Sergey Eu. Severin},
  journal={Journal of drug targeting},
  year={2010},
  volume={18 8},
  pages={575-88}
}
The alpha-fetoprotein derived growth inhibitory peptide (GIP) is a 34-amino acid peptide composed of three biologically active subfragments. GIP-34 and its three constituent segments have been synthesized, purified, and studied for biological activity. The GIP-34 and GIP-8 have been characterized as anticancer therapeutic peptides. An multicenter study was initiated to elucidate the means by which these peptide drugs could be targeted to tumor cells. The study first established which cancer… CONTINUE READING

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