Targeted delivery of anti-angiogenic agent TNP-470 using water-soluble polymer in the treatment of choroidal neovascularization.

@article{Yasukawa1999TargetedDO,
  title={Targeted delivery of anti-angiogenic agent TNP-470 using water-soluble polymer in the treatment of choroidal neovascularization.},
  author={Tsutoma Yasukawa and Hideya Kimura and Yasuhiko Tabata and Hideki Miyamoto and Yoshihito Honda and Yoshito Ikada and Yuichiro Ogura},
  journal={Investigative ophthalmology & visual science},
  year={1999},
  volume={40 11},
  pages={2690-6}
}
PURPOSE The conjugation of drugs with water-soluble polymers such as poly(vinyl alcohol) (PVA) tends to prolong the half-life of drugs and facilitate the accumulation of drugs in tissues involving neovascularization. The purpose of this study was to evaluate the effect of TNP-470-PVA conjugate on the proliferation of endothelial cells in vitro and on experimental choroidal neovascularization (CNV) in vivo. METHODS TNP-470 was conjugated in PVA by a dimethylaminopyridine-catalyzed reaction… CONTINUE READING

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Inhibition of inflammatory corneal angiogenesis by TNP-470.

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