Targeted delivery of CRISPR/Cas9 to prostate cancer by modified gRNA using a flexible aptamer-cationic liposome

@inproceedings{Zhen2017TargetedDO,
  title={Targeted delivery of CRISPR/Cas9 to prostate cancer by modified gRNA using a flexible aptamer-cationic liposome},
  author={Shuai Zhen and Yoichiro Takahashi and Shunichi Narita and Yi-Chen E. Yang and Xu Li},
  booktitle={Oncotarget},
  year={2017}
}
The potent ability of CRISPR/Cas9 system to inhibit the expression of targeted gene is being exploited as a new class of therapeutics for a variety of diseases. However, the efficient and safe delivery of CRISPR/Cas9 into specific cell populations is still the principal challenge in the clinical development of CRISPR/Cas9 therapeutics. In this study, a… CONTINUE READING