Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death.

@article{Wang2007TargetedDO,
  title={Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death.},
  author={Xin Wang and Bagirathy Nadarajah and Andrew C. Robinson and Barry W McColl and Jia-wei Jin and Federico Dajas-Bailador and Ray P. Boot-Handford and Cathy Tournier},
  journal={Molecular and cellular biology},
  year={2007},
  volume={27 22},
  pages={7935-46}
}
The c-Jun NH2-terminal protein kinase (JNK) is a mitogen-activated protein kinase (MAPK) involved in the regulation of various physiological processes. Its activity is increased upon phosphorylation by the MAPK kinases MKK4 and MKK7. The early embryonic death of mice lacking an mkk4 or mkk7 gene has provided genetic evidence that MKK4 and MKK7 have nonredundant functions in vivo. To elucidate the physiological role of MKK4, we generated a novel mouse model in which the mkk4 gene could be… CONTINUE READING
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