Targeted deletion of the lens fiber cell-specific intermediate filament protein filensin.

@article{Alizadeh2003TargetedDO,
  title={Targeted deletion of the lens fiber cell-specific intermediate filament protein filensin.},
  author={Azita Alizadeh and John I Clark and Teri Seeberger and John T. Hess and T. N. Blankenship and Paul G. Fitzgerald},
  journal={Investigative ophthalmology & visual science},
  year={2003},
  volume={44 12},
  pages={
          5252-8
        }
}
PURPOSE To determine the function of the lens fiber cell-specific cytoskeletal protein, filensin, in lens biology. METHODS Targeted genomic deletion was used to delete exon 1 and the transcriptional start site of the filensin gene. Resultant chimeric animals were bred to homozygosity for the mutant allele. These animals were outbred to mice bearing the wild-type CP49 alleles to eliminate the mutant CP49 gene carried by the 129 strain of mice. Animals homozygous for the mutated filensin gene… CONTINUE READING

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