Targeted deletion of hepatocyte ABCA1 leads to very low density lipoprotein triglyceride overproduction and low density lipoprotein hypercatabolism.

@article{Chung2010TargetedDO,
  title={Targeted deletion of hepatocyte ABCA1 leads to very low density lipoprotein triglyceride overproduction and low density lipoprotein hypercatabolism.},
  author={Soonkyu Chung and Jenelle M. Timmins and Myngan Duong and Chiara Degirolamo and Shunxing Rong and Janet K. Sawyer and Roshni R. Singaraja and Michael R. Hayden and Nobuyo N. Maeda and Lawrence Lee Rudel and Gregory S. Shelness and John S Parks},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 16},
  pages={12197-209}
}
Loss of ABCA1 activity in Tangier disease (TD) is associated with abnormal apoB lipoprotein (Lp) metabolism in addition to the complete absence of high density lipoprotein (HDL). We used hepatocyte-specific ABCA1 knock-out (HSKO) mice to test the hypothesis that hepatic ABCA1 plays dual roles in regulating Lp metabolism and nascent HDL formation. HSKO mice recapitulated the TD lipid phenotype with postprandial hypertriglyceridemia, markedly decreased LDL, and near absence of HDL. Triglyceride… CONTINUE READING