Targeted deletion of angiotensin II type 2 receptor caused cardiac rupture after acute myocardial infarction.

@article{Ichihara2002TargetedDO,
  title={Targeted deletion of angiotensin II type 2 receptor caused cardiac rupture after acute myocardial infarction.},
  author={Sahoko Ichihara and Takaaki Senbonmatsu and Edward Price and Toshihiro Ichiki and Florence A. Gaffney and Tadashi Inagami},
  journal={Circulation},
  year={2002},
  volume={106 17},
  pages={
          2244-9
        }
}
BACKGROUND Accumulating evidence has suggested that the cardiac renin-angiotensin system is activated during the remodeling process after myocardial infarction (MI). Although 2 types of angiotensin II receptors (AT(1) and AT(2)) are upregulated in the infarcted tissue, the contribution of AT(2) to the subsequent fibrogenetic phase of wound healing is less certain. This study was conducted to evaluate the role of AT(2) in wound healing after MI using an in vivo intervention study in mice with MI… CONTINUE READING

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