Targeted deletion of CD44v7 exon leads to decreased endothelial cell injury but not tumor cell killing mediated by interleukin-2-activated cytolytic lymphocytes.

@article{Mckallip2003TargetedDO,
  title={Targeted deletion of CD44v7 exon leads to decreased endothelial cell injury but not tumor cell killing mediated by interleukin-2-activated cytolytic lymphocytes.},
  author={Robert J. Mckallip and Michael T. Fisher and Yoonkyung Do and Andras K. Szakal and Ursula Gunthert and Prakash Nagarkatti and Mitzi Nagarkatti},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 44},
  pages={43818-30}
}
In the current study, we investigated the nature and role of CD44 variant isoforms involved in endothelial cell (EC) injury and tumor cell cytotoxicity mediated by IL-2-activated killer (LAK) cells. Treatment of CD44 wild-type lymphocytes with IL-2 led to increased gene expression of CD44 v6 and v7 variant isoforms and to significant induction of vascular leak syndrome (VLS). CD44v6-v7 knockout (KO) and CD44v7 KO mice showed markedly reduced levels of IL-2-induced VLS. The decreased VLS in… CONTINUE READING

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