Targeted deletion of AP-2alpha leads to disruption in corneal epithelial cell integrity and defects in the corneal stroma.

Abstract

PURPOSE The present study was undertaken to create a conditional knockout of AP-2alpha in the corneal epithelium. METHODS A line of mice expressing Cre-recombinase specifically in the early lens placode was crossed with mice in which the AP-2alpha allele is flanked by two loxP sites. The resultant Le-AP-2alpha mutants exhibited a targeted deletion of AP… (More)

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