Targeted deep sequencing reveals no definitive evidence for somatic mosaicism in atrial fibrillation.

@article{Roberts2014TargetedDS,
  title={Targeted deep sequencing reveals no definitive evidence for somatic mosaicism in atrial fibrillation.},
  author={Jason D Roberts and James Longoria and Annie Poon and Michael H. Gollob and Thomas A. Dewland and Pui-yan Kwok and Jeffrey E. Olgin and Rahul C. Deo and Gregory M. Marcus},
  journal={Circulation. Cardiovascular genetics},
  year={2014},
  volume={8 1},
  pages={
          50-7
        }
}
BACKGROUND Studies of ≤15 atrial fibrillation (AF) patients have identified atrial-specific mutations within connexin genes, suggesting that somatic mutations may account for sporadic cases of the arrhythmia. We sought to identify atrial somatic mutations among patients with and without AF using targeted deep next-generation sequencing of 560 genes, including genetic culprits implicated in AF, the Mendelian cardiomyopathies and channelopathies, and all ion channels within the genome. METHODS… CONTINUE READING

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