Targeted cleavage of hepatitis E virus 3' end RNA mediated by hammerhead ribozymes inhibits viral RNA replication.

@article{Sriram2003TargetedCO,
  title={Targeted cleavage of hepatitis E virus 3' end RNA mediated by hammerhead ribozymes inhibits viral RNA replication.},
  author={Bandi Sriram and Deepshi Thakral and Subrat Kumar Panda},
  journal={Virology},
  year={2003},
  volume={312 2},
  pages={350-8}
}
The 3' end of hepatitis E virus (HEV) contains cis-acting regulatory element, which plays an important role in viral replication. To develop specific replication inhibitor at the molecular level, mono- and di-hammerhead ribozymes (Rz) were designed and synthesized against the conserved 3' end sequences of HEV, which cleave at nucleotide positions 7125 and… CONTINUE READING