Targeted chemotherapy in mice with peritoneally disseminated gastric cancer using monoclonal antibody-drug conjugate.

@article{Okamoto1998TargetedCI,
  title={Targeted chemotherapy in mice with peritoneally disseminated gastric cancer using monoclonal antibody-drug conjugate.},
  author={Kazuhiko Okamoto and Toshiharu Yamaguchi and Eigo Otsuji and Nobuki Yamaoka and Yoshihiro Yata and Hiroshi Tsuruta and Koichi Kitamura and Takamune Takahashi},
  journal={Cancer letters},
  year={1998},
  volume={122 1-2},
  pages={
          231-6
        }
}
The murine monoclonal antibody A7 (MAb A7) is reactive against most human gastric cancer cell lines. Using a nude mouse peritoneal dissemination model of human gastric cancer, we investigated targeted chemotherapy using a conjugate of neocarzinostatin (NCS) with MAb A7 (A7-NCS). After demonstrating cytotoxicity of the complex against the human gastric cancer cell line MKN45 in vitro, we intraperitoneally injected A7-NCS, NCS or saline into nude mice bearing peritoneally disseminated human… CONTINUE READING

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