Targeted cellular metabolism for cancer chemotherapy with recombinant arginine-degrading enzymes

@inproceedings{Kuo2010TargetedCM,
  title={Targeted cellular metabolism for cancer chemotherapy with recombinant arginine-degrading enzymes},
  author={Marcus Tien Kuo and Niramol Savaraj and Lynn G. Feun},
  booktitle={Oncotarget},
  year={2010}
}
It has been shown that a subset of human cancers, notably, melanoma and hepatocellular carcinoma (HCC) are auxotrophic for arginine (Arg), because they do not express argininosuccinate synthetase (ASS), the rate-limiting enzyme for the biosynthesis of arginine from citrulline. These ASS-negative cancer cells require Arg from extracellular sources for survival. When they are exposed to recombinant Arg-degrading enzymes, e.g. arginine deiminase (ADI) or arginase, they die because of Arg… CONTINUE READING
31 Citations
44 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 31 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 44 references

- induced senescence in melanoma cells

  • GL Semenza
  • 2008

Similar Papers

Loading similar papers…