Targeted cell entry of lentiviral vectors.

  title={Targeted cell entry of lentiviral vectors.},
  author={Sabrina Funke and Andrea Maisner and Michael D. M{\"u}hlebach and Ulrike Koehl and Manuel Grez and Roberto B Cattaneo and Klaus Cichutek and Christian J Buchholz},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  volume={16 8},
Retargeting of lentiviral vector entry to cell types of interest is a key factor in improving the safety and efficacy of gene transfer. In this study we show that the retargetable envelope glycoproteins of measles virus (MV), namely, the hemagglutinin (H) responsible for receptor recognition and the fusion protein (F), can pseudotype human immunodeficiency virus 1 (HIV-1) vectors when their cytoplasmic tails are truncated. We then pseudotyped HIV-1 vectors with MV glycoproteins displaying on H… CONTINUE READING


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