Targeted capture and resequencing of 1040 genes reveal environmentally driven functional variation in grey wolves.

@article{Schweizer2016TargetedCA,
  title={Targeted capture and resequencing of 1040 genes reveal environmentally driven functional variation in grey wolves.},
  author={R. A. Meyer Schweizer and Jacqueline Robinson and Ryan J Harrigan and Pedro Silva and Marco Galverni and Marco Musiani and Richard E. Green and John Novembre and Robert K. Wayne},
  journal={Molecular ecology},
  year={2016},
  volume={25 1},
  pages={357-79}
}
In an era of ever-increasing amounts of whole-genome sequence data for individuals and populations, the utility of traditional single nucleotide polymorphisms (SNPs) array-based genome scans is uncertain. We previously performed a SNP array-based genome scan to identify candidate genes under selection in six distinct grey wolf (Canis lupus) ecotypes. Using this information, we designed a targeted capture array for 1040 genes, including all exons and flanking regions, as well as 5000 1-kb… CONTINUE READING
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